Gene Therapy MCQ Pdf
Q1. What is gene therapy?
A) A technique used to cure many hereditary diseases
B) Introducing healthy foreign genes into cells with genetic defects
C) Both of these
D) Repair defective genes to restore them to normal
Correct Answer: C
Explanation: Gene therapy involves introducing healthy genes or repairing defective ones to treat inherited disorders.
Q2. Gene therapy refers to
A) Using artificial mutagenesis to revert mutations
B) Removing defective genes to cure diseases
C) Introducing healthy foreign genes into defective cells
D) Repairing genes to restore them
Correct Answer: C
Explanation: The main mechanism of gene therapy is to deliver functional genes into genetically defective cells.
Q3. A person with a hereditary disease can be cured using
A) Gene therapy
B) Cloning
C) Dialysis
D) Chemotherapy
Correct Answer: A
Explanation: Gene therapy targets the root cause of hereditary diseases by correcting gene-level defects.
Q4. What are the types of gene therapy?
A) Somatic gene therapy
B) Germline gene therapy
C) Both of these
D) None of these
Correct Answer: C
Explanation: Gene therapy includes somatic (non-reproductive cells) and germline (reproductive cells) approaches.
Q5. The most effective treatment for albinism is
A) Gene therapy
B) Psychotherapy
C) X-ray therapy
D) General drug treatment
Correct Answer: A
Explanation: Albinism is caused by genetic mutation; gene therapy targets and corrects the defective gene.
Q6. The first gene therapy in 1990 treated deficiency of
A) Smallpox
B) Vitamin E
C) Protein
D) Adenosine deaminase
Correct Answer: D
Explanation: The first clinical gene therapy was for ADA-SCID, caused by adenosine deaminase deficiency.
Q7. Gene therapy introduces healthy foreign genes into
A) DNA molecules with defects
B) Chromosomes with defects
C) Defective organelles
D) Genetically defective cells
Correct Answer: D
Explanation: Gene therapy directly targets the defective cells to restore their function.
Q8. In the first step of gene therapy, ______ are cultured from patient’s blood.
A) Red blood cells
B) Lymphocytes
C) Neurons
D) Platelets
Correct Answer: B
Explanation: Lymphocytes are often used in gene therapy experiments as they are nucleated and easy to modify.
Q9. DNA probes can detect
A) Endemic goiter
B) Hepatitis B
C) Osteomalacia
D) Iron deficiency anemia
Correct Answer: B
Explanation: DNA probes are widely used to detect viral infections like Hepatitis B.
Q10. Which kind of disease can be cured with gene therapy?
A) Infectious
B) Hereditary
C) Physiological
D) Acute
Correct Answer: B
Explanation: Gene therapy primarily targets inherited genetic disorders.
Q11. Gene therapy cures inherited diseases by
A) Altering genes inside body’s cells
B) Degrading faulty genes
C) Generating new genes
D) All of these
Correct Answer: A
Explanation: Gene therapy works by modifying the existing genes within body cells.
Q12. Which of the following is not part of gene therapy?
A) Replacing defective genes
B) Stimulating immunity via gene transfer
C) Inhibiting oncogene transcription
D) Intake of “healthy genes” orally
Correct Answer: D
Explanation: Healthy genes cannot be taken orally; they must be introduced into cells via vectors.
Q13. Which virus is not used in gene therapy?
A) Papillomavirus
B) Retrovirus
C) Adenovirus
D) Herpes simplex virus
Correct Answer: A
Explanation: Papillomavirus is not typically used as a vector due to safety and integration limitations.
Q14. Which of the following is true about gene therapy?
A) It repairs defective cells to normal
B) Uses artificial mutagenesis
C) Removes defective genes
D) Used only for infectious diseases
Correct Answer: A
Explanation: Gene therapy works by introducing functional genes, effectively repairing defective ones.
Q15. Which statement about gene therapy is incorrect?
A) It treats recessive genetic diseases
B) Involves introducing healthy genes
C) Is still in clinical trials
D) Guarantees complete cure for future generations
Correct Answer: D
Explanation: Somatic gene therapy does not affect germ cells, so it cannot ensure inheritance of the correction.